Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
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چکیده
منابع مشابه
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.
Most of our understanding of G protein-coupled receptor (GPCR) activation has been focused on the direct interaction between diffusible ligands and their seven-transmembrane domains. However, a number of these receptors depend on their extracellular N-terminal domain for ligand recognition and activation. To dissect the molecular interactions underlying both modes of activation at a single rece...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2012
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1008